Colorectal cancer liver metastasis

This video shows the application of the Quest Spectrum Platform for the detection of colorectal cancer liver metastasis.
After the injection of ICG the metastasis are shown as green rings around the metastasis. This procedure can be performed both open as shown here, and laparoscopically.

Near-infrared fluorescent imaging identifies significantly more and smaller tumors during resection of colorectal cancer liver metastasis, preventing recurrences in a subset of patients. Given its safety profile and low expense, routine use of ICG can be considered until tumor targeting fluorescent tracers are clinically available.

Links to supporting literature:

Near-infrared fluorescence-guided resection of colorectal liver metastases.
Van der Vorst et al.,
Cancer 2013. Sep 15 ;119(18):3411-8

Long-term follow-up after near-infrared fluorescence-guided resection of colorectal liver metastases: A retrospective multicenter analysis
Handgraaf et al.
European Journal of Surgical Oncology , Volume 43 , Issue 8 , 1463 – 1471

Motivations to choose ICG in case of colorectal cancer liver metastasis:

  • In 13% of the cases more metastasis are detected
  • Lesions are undetectable by preoperative computed tomography, intraoperative ultrasound, visual inspection, and palpation
  • Only superficial lesions are detected but it seems that the majority of lesions are superficial


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