Visualization of Tumors with the Quest Spectrum™ Platform

The Quest Spectrum™ Platform can be used for visualization of tumors. Tumors are widely known for their rapid generation time an increased energy consumption. In order to prevent a full collapse of the tumor cells due to nutrient deprivation or self-pollution, the tumor cells induce angiogenesis. The new blood vessels generated from pre-existing vessels increase the blood flow to the tumors. However, some of these vessels might suffer from lower perfusion as a result of improper development. These blood vessels can be visualized with help of the Quest Spectrum™ Platform.

In order to visualize the blood vessels surrounding the tumors a patient is injected with a substantial amount of Indo Cyanine Green (ICG). ICG accumulates in all blood vessels of the targeted organ making all blood vessels susceptible for fluorescent imaging. Then, the injection of ICG will be stopped. This will cause a difference in the ICG concentration between properly and improperly perfused blood vessels; the ICG concentration in healthy blood vessels decrease rapidly, while the concentration in tumor induced blood vessels will decrease slowly. This contrast can be visualized with the Quest Spectrum™ Platform for tumor localization.

Colorectal Cancer Liver Metastasis

Visualization of liver metastases

Visualization of liver metastases with the Quest Spectrum™ Platform is shown above. On the left, the natural image is shown which the surgeon can see with the naked eye. On the right, the fluorescent response of the ICG tracer is shown. This image shows four circular shaped structures. The middle images overlays the fluorescent image in green upon the natural image. In this image the tumors are clearly visualized, which shows the benefit of fluorescent imaging with the Quest Spectrum™ Platform. Surgeons can with help of the Quest Spectrum™ Platform make better decisions for removal of tumors.

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